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8-Hydroxydeoxyguanosine in vitro: Effects of glutathione, ascorbate, and 5-aminosalicylic acid

โœ Scribed by Anne Fischer-Nielsen; Henrik E. Poulsen; Steffen Loft

Book ID
113385725
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
626 KB
Volume
13
Category
Article
ISSN
0891-5849

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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti