752 The apolipoprotein E e4 allele in Parkinson disease with and without Alzheimer lesions
✍ Scribed by R. Egensperger; C. Bancher; S. Kösel; K. Jellinger; P. Mehraein; M.B. Graeber
- Book ID
- 117414153
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 142 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0197-4580
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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐
Recent studies have 'found an association between presence of apolipoprotein E (APOE) €4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the €4 allele with the relative