Low Prevalence of Apolipoprotein E E4 Allele in Filipinos with Alzheimer’s Disease
✍ Scribed by Cristine Casingal; Dianne Florendo; Alicia Alfon; Maria Luisa Daroy; Cynthia Mapua; Ronald Matias; Jacqueline Dominguez
- Book ID
- 118467363
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 48 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1552-5260
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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐
Recent studies have 'found an association between presence of apolipoprotein E (APOE) €4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the €4 allele with the relative