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73 Innate Dysfunction and Linear Growth Failure in Pediatric Crohn Disease

โœ Scribed by Sharon D'Mello; Anna Trauernicht; Erin L. Bonkowski; Tara Willson; Subra Kugathasan; Lee Denson


Book ID
119429920
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
56 KB
Volume
136
Category
Article
ISSN
0016-5085

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Background: Growth failure remains a common complication of pediatric Crohn's disease (CD) and has been associated with small bowel involvement and need for surgery. We have reported that patients with elevated (!1.6 lg/mL) granulocyte macrophage colony stimulating factor autoantibodies (GM-CSF Ab)

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Growth retardation (GR) may pose a significant challenge to the quality of life and the proper management of children and adolescents with Crohn's disease (CD). It can occur in a significant proportion of patients, and may precede clinical evidence of bowel disease. Current evidence suggests that GR