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721 ETHANOL-INDUCED CYTOCHROME P450 2E1 CAUSES CARCINOGENIC ETHENO-DNA LESIONS IN ALCOHOLIC LIVER DISEASE

✍ Scribed by Y. Wang; G. Millonig; J. Nair; E. Patsenker; F. Stickel; S. Mueller; H. Bartsch; H.K. Seitz

Book ID
117377728
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
49 KB
Volume
50
Category
Article
ISSN
0168-8278

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Cytochrome P-450 2E1 is a specific isozyme of cytochrome P-450 induced by ethanol. P-450 2E1 may also be the only enzyme that metabolizes N-nitrosodimethylamine at a very low concentration. Because N-nitrosodimethylamine is a procarcinogen, the possibility that induction of P-450 2El by alcohol abus