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72 Characterization of S182 (presenilin 1) and its effect on ßA4

✍ Scribed by M. Staufenbiel; K.-H. Baumann; C. Sturchler-Pierrat; K.-H. Wiederhold; A. Probst; P. Paganetti; P. Frey; B. Yankner; B. Sommer

Book ID
118577859
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
138 KB
Volume
17
Category
Article
ISSN
0197-4580

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✍ Tyrrell, Janette; Cosgrave, Mary; McPherson, Janet; Hawi, Ziarih; Trulock, Vivie 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 24 KB 👁 2 views

As people with Down syndrome (DS) age, they are at greater risk for Alzheimer disease (AD) than the general population. It has been suggested that polymorphisms at the genes for presenilin-1 (PS-1) and ␣-1antichymotrypsin (ACT) confer an increased risk for AD in the general population, and therefore