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443 Characterization of presenilin 1 (PS1) with mutations linked to familial Alzheimer's disease: Metabolism, topology and influence on Aβ generation

✍ Scribed by G. Thinakaran; A. Doan; M.K. Lee; H.H. Slunt; M. Savage; B. Greenberg; R. Wang; D.L. Price; S.S. Sisodia


Book ID
117413998
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
139 KB
Volume
17
Category
Article
ISSN
0197-4580

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison