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713 [11C]Methyl-EXP3174 as a Potential Radioligand for Imaging AT1Receptor With Pet

โœ Scribed by B. Ismail; J. Fabre; T. Hadizad; J. Thackeray; S. Thorn; R. DeKemp; R. Beanlands; J. DaSilva

Book ID
116364264
Publisher
Pulsus Group Inc
Year
2012
Tongue
English
Weight
375 KB
Volume
28
Category
Article
ISSN
0828-282X

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## Abstract __Introduction:__ (__R__)โ€3โ€(2โ€(methylthio)phenoxy)โ€__N__โ€methylโ€3โ€phenylpropanโ€1โ€amine [(__R__)โ€“thionisoxetine; **1**] is a potent inhibitor of the norepinephrine transporter (NET). We aimed to label **1** with carbonโ€11 (__t__~1/2~ = 20.4 min) for evaluation as a radioligand for imagi