๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

7-Substituted 6-nitro analogs of oxolinic acid

โœ Scribed by R. G. Glushkov; L. N. Dronova; A. S. Elina; M. V. Porokhovaya; E. N. Padeiskaya; T. P. Radkevich; L. D. Shipilova

Book ID
112400365
Publisher
Springer
Year
1989
Tongue
English
Weight
285 KB
Volume
23
Category
Article
ISSN
0091-150X

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Swainsonine (1), an inhibitor of the important glycoprotein-processing enzyme Golgi a-mannosidase II, is a clinical candidate for cancer treatment. Analogs bearing substituents at C-6 and C-7 have been prepared and evaluated as inhibitors of a-mannosidase (jack bean), a closely related enzyme.