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7-Oxo-4,5,6,7-tetrahydro-1 H -pyrazolo[3,4- c ]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase

โœ Scribed by Duplantier, Allen J.; Andresen, Catharine J.; Cheng, John B.; Cohan, Victoria L.; Decker, Christian; DiCapua, Frank M.; Kraus, Kenneth G.; Johnson, Kerry L.; Turner, Claudia R.; UmLand, John P.; Watson, John W.; Wester, Ronald T.; Williams, Alison S.; Williams, John A.


Book ID
121373498
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
260 KB
Volume
41
Category
Article
ISSN
0022-2623

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## Abstract A facile synthesis of __trans__ isomers of 4โ€arylโ€3โ€methylโ€6โ€oxoโ€4,5,6,7โ€tetrahydro**โ€**2__H__**โ€**pyrazolo[3,4โ€__b__]pyridineโ€5โ€carbonitriles via threeโ€component condensation reaction of an aldehyde, 3โ€aminoโ€5โ€methylpyrazole and ethyl cyanoacetate in acetonitrile has been developed und