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7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro

✍ Scribed by Saurabh Luthra; Joyce Dong; Ana L. Gramajo; Marilyn Chwa; Dae W. Kim; Aneesh Neekhra; Baruch D. Kuppermann; M. Cristina Kenney

Book ID
116760722
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
607 KB
Volume
75
Category
Article
ISSN
0026-2862

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Cholesterol oxides have numerous cytotoxic effects and those oxidized in the C7 position have been shown to induce apoptosis in bovine aortic endothelial cells (BAEC). The aim of the present study was to determine whether apoptosis also occurs in human vascular endothelial cells (HUVEC) treated with