7. Conjugate addition of organocopper reagents to steroidal polyenones
โ Scribed by P.N. Rao; D.M. Peterson
- Book ID
- 116001045
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 97 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0022-4731
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Mediated by a noncovalently bound chiral amidophosphine iigand I, reaction of organocoppers with cycloalkenones 2 aforded the corresponding J-substituted cyclo-aLk-anones 3 in 9568% ee.
Chlorotrimethylsilane, particularly if combined with hexamethylphosphoric triamide or 4\_dimethylaminopyridine, strongly promote the conjugate addition of stoichiometric organocopper reagents.
N-Tosylated cx, S-unsaturated amides and lactams undergo facile conjugate addition with R'CuLi or RMgX/CuI (cat.). Stereoselective synthesis of trans-S,y-dialkyl-y-lactams