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7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)- 4-oxo-1,2,4-triazolo[1,5- a ]quinoxaline-2- carboxylates as Novel Highly Selective AMPA Receptor Antagonists

✍ Scribed by Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Cecchi, Lucia; Filacchioni, Guido; Galli, Alessandro; Costagli, Chiara; Carlà, Vincenzo


Book ID
126964086
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
46 KB
Volume
43
Category
Article
ISSN
0022-2623

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## Abstract 5′‐Mercapto‐1′__H__‐1,2,4‐triazol‐3′‐yl‐isoquinolinium salts **(6)** were synthesised by the reaction of __ortho__‐acyl phenylacetones **(2)** or the corresponding pyrylium salts **(3)** and 5‐amino‐2,3‐dihydro‐1__H__‐1,2,4‐triazole‐3‐thione **(5)**. Treatment of thioles **6** withα,ω‐d