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7-Chloro-4-methyl-6-nitro-2H-chromen-2-one: a novel type of reagent for fluorescence analysis

✍ Scribed by Christian R. Noe; Spyridon Kornilios; Bodo Lachmann

Book ID
104252731
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
144 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Starting from 7-chloro-4-methyl-2H-chromen-2-one 1 we have obtained a new reagent for fluorescence analysis. The synthesised key compound 7-chloro-4-methyl-6-nitro-2H-chromen-2-one 2 forms highly fluorescent derivatives with different amines, which can be introduced by nucleophilic substitution of the chloro atom. Two examples are given which describe the preparation of these derivatives. Additionally, we demonstrate that an increase of fluorescence can be achieved, if a reduction step is performed after the substitution.

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