## Abstract Cytochrome P450 (P450) enzymes catalyze a variety of oxidation and some reduction reactions, collectively involving thousands of substrates. A general chemical mechanism can be used to rationalize most of the oxidations and involves a perfenyl intermediate (FeO^3+^) and oddβelectron che
7-Aminocoumarins Are Substrates of Cytochrome P450-Isozymes
β Scribed by Martin Tegtmeier; Wolfgang Legrum
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 129 KB
- Volume
- 331
- Category
- Article
- ISSN
- 0365-6233
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The substrate specificity of a camphor-induced cytochrome P-450 (P-450 cam ) was measured by using a new assay system: electrochemical control of P-450 cam activity by protein immobilization on an electrode. Immobilized P-450 cam showed the obvious substrate specificity for hydroxylation of the subs
Eight methylenedioxyphenyl (MDP) compounds were examined for their ability to induce cytochrome P450 (P450) in mouse liver. Induction by safrole, isosafrole, and dihydrosafrole was studied in both C57BLl6N (Ah-responsive) and DBA/2N (Ahnonresponsive) male mice after IP administration of 200 mglkglda
Benzphetamine, an amphetamine with sympathomimetic stimulant activity in the central nervous system, is a substrate for cytochromes P450 with highest metabolic turnover being catalyzed by cytochrome P4502B1. We synthesized three photolabile azido-compound analogs, \(\quad N\)-( \(p\)-azidobenzyl)- \