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65. 31P NMR of phospholipids in postmortem schizophrenic brains

✍ Scribed by R.A. Komoroski; J.M. Pearce; W.S.T. Griffin; R.E. Mrak; C.N. Karson; M. Omori

Book ID
119407732
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
19 KB
Volume
47
Category
Article
ISSN
0006-3223

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31P NMR spectroscopy of phospholipid met
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## Abstract Evidence has been accumulating that schizophrenia involves abnormalities in the composition and metabolism of cell membrane phospholipids (PLs) in the brain. In vivo ^31^P MRS has been used to measure the metabolic precursors and degradation products of PL metabolism in schizophrenia. B

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## Abstract Cell membrane abnormalities due to changes in phospholipid (PL) composition and metabolism have been implicated in schizophrenia pathogenesis. That work has generally assessed membrane phospholipids from nonneural tissues such as erythrocytes and platelets. High‐resolution ^31^P NMR spe

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The in vivo dog brain "P NMR spectrum has a large peak in the phosphodiester region accounting for more than 35% of the total observable phosphorus metabolites. It is possible to reduce the intensity of this peak by off-resonance saturation. To characterize the nature of this peak, extracts of dog b

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Techniques are described for the (31)P NMR analysis of glycerophospholipid (PL) headgroup and molecular species in brain. The (31)P NMR spectrum of PLs from human temporal cortex, solubilized in aqueous Na cholate, typically showed 3 major resonances, assigned to phosphatidylcholine (PC) molecular s