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625 A naturally occurring constitutively variant of the epidermal growth factor receptor increases cell motility

✍ Scribed by M.W. Pedersen; V. Tkach; N. Pedersen; V. Berezin; H.S. Poulsen

Book ID
118620798
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
173 KB
Volume
1
Category
Article
ISSN
1359-6349

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## Abstract Tumor cell motility is one of the rate‐limiting steps of invasion, which defines progression toward a more malignant phenotype. Elevated expression of epidermal growth factor receptor (EGFR) in many cancers is associated with progression of superficial to invasive forms of the disease.