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623 Safety and pharmacokinetics of NM107 following intravenous infusion of escalating doses in healthy volunteers: Determination of absolute oral bioavailability of valopicitabine (NM283)

✍ Scribed by X.J Zhou; S. Knox; B. Fielman; G. Chao; N. Brown


Book ID
117374899
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
220 KB
Volume
44
Category
Article
ISSN
0168-8278

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In this first part of a two-part investigation, the intravenous dose proportionality of dolasetron mesylate, a 5-HT 3 receptor antagonist, and the absolute bioavailability of oral dolasetron mesylate were investigated. In an open-label, randomized, four-way crossover design, 24 healthy men between t