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Pharmacokinetics and bioavailability of denaverine hydrochloride in healthy subjects following intravenous, oral and rectal single doses

✍ Scribed by Alexander Staab; Barbara S Schug; Véronique Larsimont; Martina Elze; Daniela Thümmler; Ernst Mutschler; Henning Blume

Book ID
118606085
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
245 KB
Volume
18
Category
Article
ISSN
0928-0987

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Nicardipine HCI oral doses (10-40 mg) were administered sequentially to six healthy subjects. For each regimen the capsule dose was administered every 8 hours (q 8 h) for 3 days and the plasma profiles of nicardipine and its pyridine analogue (M5) were determined following the last dose on day 4. St