616 Expression of hMLH1 and hMSH2 proteins in normal tissues and cancer predisposition in hereditary non-polyposis colon cancer
โ Scribed by P. Plevova; E. Sedlakova; J. Zapletalova; Z. Kolar
- Book ID
- 118620789
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 166 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1359-6349
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We have screened 17 Southern Sweden individuals/families with suspected hereditary non-polyposis colorectal cancer (HNPCC) for mutations in the DNA-mismatch repair genes hMLH1, hMSH2 and hMSH6 using denaturing gradient gel electrophoresis, protein truncation test and direct DNA sequencing. The famil
## Abstract ## Background hMLH1 and hMSH2 have been implicated to be involved in the DNA mismatch repair (MMR) system. The purpose of this study is to investigate the expression of hMLH1 and hMSH2 DNA MMR proteins in nonโsmall cell lung cancer (NSCLC) tissue and to elucidate their clinical signifi