613 Homozygous deletions of human chromosome 3p in lung tumors
โ Scribed by Todd, S.; Franklin, W.A.; Varella-Garcia, M.; Kennedy, T.; Hilliker, C.E.; Hahner, L.; Anderson, M.; Wiest, J.S.; Drabkin, H.A.; Gemmill, R.M.
- Book ID
- 122011150
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 160 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0169-5002
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## Background: The origins of and interrelations between low grade and high grade neuroendocrine lung tumors, typical and atypical carcinoids, and small cell lung carcinoma (sclc) have not been elucidated. karyotypic and molecular genetic studies have demonstrated deletions in 3p in 100% of sclcs a
We examined 149 lung cancer cell lines for homozygous deletions using 24 DNA markers, which were mapped and ordered in chromosome band 9p21, to define the target regions for 9p21 deletions in human lung cancer. Homozygous deletions were detected in 39 (26%) cell lines and clustered at 2 independent