𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Frequent Germline Deletion Polymorphism of Chromosomal Region 8p12–p21 Identified as a Recurrent Homozygous Deletion in Human Tumors

✍ Scribed by Byungwoo Ryu; Jason Song; Taylor Sohn; Ralph H. Hruban; Scott E. Kern

Book ID
115615359
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
124 KB
Volume
72
Category
Article
ISSN
0888-7543

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Identification of a homozygous deletion
Identification of a homozygous deletion at 8p12–21 in a human prostate cancer xenograft
✍ Dirk C. Van Alewijk; Marcel M. Van Der Weiden; Bert J. Eussen; Lydia D. Van Den 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 1 views

One of the most frequent genetic abnormalities in prostate cancer is loss of the complete or part of the short arm of chromosome 8, indicating the localization of one or more tumor suppressor genes on this chromosomal arm. Using allelotyping, a frequently deleted region in prostate cancer in a genet

Homozygous and frequent deletion of prox
Homozygous and frequent deletion of proximal 8p sequences in human prostate cancers: Identification of a potential tumor suppressor gene site
✍ Madhu A. Prasad; Tanya M. Trybus; Kirk J. Wojno; Jill A. Macoska 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB 👁 2 views

By using tissue microdissection and polymerase chain reaction (PCR) techniques, we examined 85 prostate tumors that were paired with normal tissues from the same patients for allelic loss at 26 highly polymorphic microsatellite sequences, 21 spanning 8p and 5 localized to 8q. Sixty-four tumors (75%)

Localization of the human HF.10 finger g
Localization of the human HF.10 finger gene on a chromosome region (3p21–22) frequently deleted in human cancers
✍ Emilio Donti; Luisa Lanfrancone; Kay Huebner; Anna Pascucci; Giovanna Venti; Gin 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 642 KB

The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We