6-endo versus 5-exo Radical Cyclization: Streamlined Syntheses of Carbahexopyranones and Derivatives by 6-endo-trig Radical Cyclization.
โ Scribed by Ana M. Gomez; Maria D. Company; Clara Uriel; Serafin Valverde; J. Cristobal Lopez
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 32 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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A successful synthesis of pterocarpans 1, based on a ''disfavored'' 5-endo-trig radical cyclization reaction, has been accomplished. The radical precursor 4-(2ะ-bromoaryloxy)-2Hchromene 8 was synthesized in six steps, starting from aryl propynyl ether 2. On treatment with tributyltin hydride in refl