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6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists

✍ Scribed by David Orain; Silvio Ofner; Manuel Koller; David A. Carcache; Wolfgang Froestl; Hans Allgeier; Vittorio Rasetti; Joachim Nozulak; Henri Mattes; Nicolas Soldermann; Philipp Floersheim; Sandrine Desrayaud; Joerg Kallen; Kurt Lingenhoehl; Stephan Urwyler


Book ID
113496463
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
510 KB
Volume
22
Category
Article
ISSN
0960-894X

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The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of th