Synthesis of (25R)-5α- 6β,15α,16β, a Cytostatic Starfish Steroid. -The title steroid (VII) is synthesized from diosgenin (I). The key step is the oxidation of the enolsilane (IV) with dimethyldioxirane to introduce the 15α-hydroxy group. -(IZZO, I.; DE
5α-cholestane-3β,6β,15α,16β,26-pentol: a polyhydroxylated sterol from the starfish Hacelia attenuata
✍ Scribed by L Minale; C Pizza; F Zollo; R Riccio
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 220 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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Asterosaponins A and B were first isolated from the Japanese starfish, Asterias amurensis, by Yasumoto et al.' --who recognized that the both saponins contain the same aglycones being attached with four or five molecules of sugars and a molecule of sulfuric acid. 2-5 Subsequently, we isolated the
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In continuation of our work' on starfish saponins, we report the isolation of the hitherto unknown 17~-methyl-3S,6cc-dihydroxy-18-no~5~-cholesta-9(ll)-l3-dien-23-one (I) from the sapoge nin portion of Astropecten aurantiacus, and show that it is an artefact produced during acid hydrolysis. Compound