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589 Involvement of Osteopontin in the Matrix Degrading and Proangiogenic Changes Mediated by Nicotine in Pancreatic Cancer Cells

โœ Scribed by Lazar, Melissa; Sullivan, Jennifer; Aziz, Tamer; Chipitsyna, Galina; Yeo, Charles J.; Arafat, Hwyda A.


Book ID
123372465
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
62 KB
Volume
138
Category
Article
ISSN
0016-5085

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## Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with etiological association with cigarette smoking. Nicotine, an important component of cigarettes, exists at high concentrations in the bloodstream of smokers. Osteopontin (OPN) is a secreted phosphoprotein that confers on can