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583 PI3-kinase inhibition enhances ABT-737 induced apoptosis in colorectal cancer cell lines

✍ Scribed by C. Morrow; O. Denneny; M. Mehibel; C. Dive


Book ID
119603266
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
58 KB
Volume
8
Category
Article
ISSN
1359-6349

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## Abstract Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival of colorectal tumour cells is dependent upon a small number of highly activated signalling pathways, th