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551 Functional characteristics of human epidermal growth factor receptor (EGFR) polymorphisms

✍ Scribed by A.A. Adjei; H. Huang; G.K. Dy; O.E. Salavaggione; C. Endo; C. Yu

Book ID: 119603234
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 46 KB
Volume: 8
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(10)72258-8

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## Abstract Epidermal growth factor receptor (EGFR) plays a critical role in mediating ultraviolet (UV) irradiation‐induced signal transduction and gene expression in human keratinocytes. EGFR activation results from increased phosphorylation on specific tyrosine residues in the C‐terminal intracel