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542 Abnormalities of FHIT and the FRA3B fragile site at 3p14.2 in lung cancer and associated preneoplastic lesions

✍ Scribed by Fong, K.M.; Biesterveld, E.J.; Virmani, A.; Wistuba, I.I.; Sekido, Y.; Bader, S.A.; Ahmadian, M.; Ong, S.T.; Rassool, F.; Zimmerman, P.V.; Giaccone, G.; Gazdar, A.F.; Minna, J.D.

Book ID
121979608
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
150 KB
Volume
18
Category
Article
ISSN
0169-5002

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Precise localization of the FHIT gene to
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✍ S. Tiong Ong; Kwun M. Fong; Scott A. Bader; John D. Minna; Michelle M. Le Beau; πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 154 KB πŸ‘ 2 views

Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s