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537 Analysis of the Codon 72 Polymorphism of P53 Gene in Patients With Multinodular Goiter to Develop Thyroid Cancer

✍ Scribed by B. Bayram; R. Sonmez; S. Bozari; H. Onlu


Book ID
117663032
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
52 KB
Volume
48
Category
Article
ISSN
0959-8049

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This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G4C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and wer

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The original article to which this Erratum refers was published in Human Mutation 24: 21-34 (2004). Using a newly developed method-Arrayed Primer Extension (APEX) and direct sequencing of exon 10 and 11 to reanalyze for TP53 sequence alterations-13 new mutations were identified. In addition, a few