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527 MOPP/ABVD and radiotherapy in the treatment of pediatric hodgkin's disease (HD)

✍ Scribed by I. Golubicic; M. Nikitovic; Z. Barjaktarevic; N. Rasovic; S. Aleksandric; V. Sobic


Book ID
116167280
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
280 KB
Volume
31
Category
Article
ISSN
0959-8049

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πŸ“œ SIMILAR VOLUMES


Treatment of childhood Hodgkin's disease
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Seventeen previously untreated children with Hodgkin's disease were treated with six courses of the combination adriamycin, bleomycin, vinblastine, and DTIC (ABVD), without radiotherapy, from 1984-1987. In all patients, complete remission was attained. After a median follow-up period of 73.5 months

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Since the introduction of mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy, children with Hodgkin's disease (HD) have been treated with chemotherapy alone. The occurrence of side effects related to irradiation (especially secondary solid tumors) is less likely to occur.

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twenty-seven patients with advanced Hodgkin's disease who failed MOPP (nitrogen mustard, vincristine, procarbazine and prednisone) were treated with adriamycin, bleomycin, vinblastine, and imidazole carboxamide, (ABVD). Complete response (CR) was achieved in 22% of patients and partial response was