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Treatment of childhood Hodgkin's disease with ABVD without radiotherapy

✍ Scribed by Behrendt, Henk; Brinkhuis, Mariël; Van Leeuwen, Eleonore F.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
372 KB
Volume
26
Category
Article
ISSN
0098-1532

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✦ Synopsis

Seventeen previously untreated children with Hodgkin's disease were treated with six courses of the combination adriamycin, bleomycin, vinblastine, and DTIC (ABVD), without radiotherapy, from 1984-1987. In all patients, complete remission was attained. After a median follow-up period of 73.5 months (range 5%98 months), five patients had a relapse after 4, 5, 11, 21, and 34 months, respectively, from attainment of complete remission. In 12 patients with stages I and II, two relapses occurred. Three out of five patients with stage Ill and stage IV developed a relapse. Based upon these results, we conclude that ABVD might be an appropriate treatment for newly diagnosed children with Hodgkin's disease stages I and II. However, for children with stages Ill and IV, more intensive treatment is needed. Radio-therapy should be withheld for children with refractory disease, residual disease, or relapse.

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