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52. Transforming growth factor-β (TGF-β) inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I

✍ Scribed by Furukawa, Y; Ohta, M; Tsunoda, A; Griffin, JD; Saico, M


Book ID
122738579
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
127 KB
Volume
46
Category
Article
ISSN
0753-3322

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TGF-β1 inhibits DNA synthesis and phosph
✍ Dr. Robert H. Whitson Jr.; Keiichi Itakura 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 950 KB

In the rat liver epithelial cell line, WB, the ability of TGF-P, to inhibit DNA synthesis was shown to correlate with its ability to inhibit phosphorylation of the protein product of the retinoblastoma susceptibility gene, pRb. When WB cells were serum-starved, then refed with serum-containing mediu