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52. Parathyroid hormone receptor protein and its receptor expression in primary breast carcinomas — prognostic significance

✍ Scribed by S.E. Downey; J.A. Hoyland; J. Walls; W.A. Ratcliffe; R. Edwards; A.J. Freemont; N.J. Bundred

Book ID: 113404560
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 154 KB
Volume: 4
Category: Article
ISSN: 0960-9776
DOI: 10.1016/0960-9776(95)90144-2

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Parathyroid hormone-related protein (PTHrP) is the cause of humoral hypercalcaemia of malignancy and interacts with parathyroid hormone (PTH) receptors. Breast cancer cells produce PTHrP in vitro and in vivo. The breast cancer cell line MCF-7, which products PTHrP and expresses PTHrP receptors, prol