Studies of breast cancer suggest that parathyroid hormone-related protein (PTHrP) is important in the development of bone metastases. To determine whether PTHrP expression is important in prostate cancer metastasis, immunohistochemistry and in situ hybridization were used to assess the expression of
The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells
✍ Scribed by Hoey, R P; Sanderson, C; Iddon, J; Brady, G; Bundred, N J; Anderson, N G
- Book ID
- 109997479
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 144 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Parathyroid hormone-related protein (PTHrP) is the cause of humoral hypercalcaemia of malignancy and interacts with parathyroid hormone (PTH) receptors. Breast cancer cells produce PTHrP in vitro and in vivo. The breast cancer cell line MCF-7, which products PTHrP and expresses PTHrP receptors, prol
## Abstract Parathyroid hormone‐related peptide (PTHrP) and parathyroid hormone (PTH)/PTHrP‐receptor, PTH/PTHrP‐R, are frequently expressed in mammary carcinomas as well as in bone cells. In this study we compared the ligand binding characteristics of the PTH/PTHrP–R in SaOS‐2 human osteosarcoma ce
## Abstract Periostin, a matricellular protein, is overexpressed in the stroma of several cancers. The aim of our study was to investigate more specifically whether periostin expression is associated with bone metastases from breast cancer and to determine its source in the affected bone. Nude mice
## Abstract ## BACKGROUND Parathyroid hormone‐related protein (PTH‐rP) is a major cause of tumor‐induced hypercalcemia (TIH) and frequently is found to be elevated in serum of patients with TIH. In the current study, the authors examined the usefulness of PTH‐rP measurement at the time of first pr