Comparison of a new antidepressive, lofe
Comparison of a new antidepressive, lofepramine, with imipramine in a double-blind multicentre trial
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B. Woggon; J. Angst; M. Bleuler; Th. L. J. Dittmer; K. Heinrich; H. Hippius; H.
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Article
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1975
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Springer-Verlag
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English
⚖ 335 KB
Lofepramine, an imipramine derivative, shows lower acute toxicity in animals when compared with desipramine and imipramine. Its anticholinergic effect is less pronounced than that of desipramine. In an open clinical trial lofepramine showed a marked antidepressive action. A double-blind multicenter