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✦   LIBER   ✦

50years of gene therapy—A contribution of Wacław Szybalski to science and humanity

✍ Scribed by Dulak, Jozef; Uchto, Joanna; Jozkowicz, Alicja

Book ID
122033651
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
419 KB
Volume
525
Category
Article
ISSN
0378-1119

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## Abstract In 1956, I decided to apply my experience in microbial genetics to developing analogous systems for human cell lines, including the selection of mutants with either a loss or gain of a biochemical function. For instance, mutants resistant to azahypoxanthine showed a loss of the HPRT enz