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−509C>T polymorphism in the TGF-β1 gene promoter is not associated with susceptibility to and progression of colorectal cancer in Chinese

✍ Scribed by P. Qi; C.-P. Ruan; H. Wang; F.-G. Zhou; Y.-P. Zhao; X. Gu; C.-F. Gao


Book ID
109043585
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
69 KB
Volume
12
Category
Article
ISSN
1462-8910

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## Abstract Matrix metalloproteinases (MMPs) play an important role in several steps of cancer development. A single guanine insertion polymorphism (2G) in the __MMP1__ promoter sequence at −1,607 creates an Ets binding site and thus results in enhancing transcriptional activity. This study aimed t