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506 THE RAS INHIBITOR FARNESYLTHIOSALICYLIC ACID INHIBITS THE GROWTH OF HEPATOCARCINOMA CELL LINES IN VITRO AND IN VIVO

✍ Scribed by N. Charette; V. Lannoy; C. De Saeger; I. Leclercq; Y. Horsmans; P. Stärkel


Book ID
117377515
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
48 KB
Volume
50
Category
Article
ISSN
0168-8278

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Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a charact