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50. The pharmacological chaperone AT1001 and treatment of Fabry disease

✍ Scribed by Richie Khanna; Elfrida R. Benjamin; Rebecca Soska; Yi Lun; Sheela A. Sitaraman; David J. Palling; David J. Lockhart; Kenneth J. Valenzano


Book ID
116988235
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
42 KB
Volume
93
Category
Article
ISSN
1096-7192

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## Abstract A series of __O__‐alkyl iminoxylitol derivatives was synthesized and evaluated as β‐glucocerebrosidase (GCase) inhibitors. This structure–activity study shows a dramatic influence of the position of the alkyl chain (α‐C1, O2, O3, or O4) on human GCase inhibition. Remarkably, 1,2‐shift o