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50 Mutations in the presenilin I and II genes are rare in early-onset Alzheimer's disease in Sweden

✍ Scribed by C. Forsell; S. Froelich; K. Axelman; P.H. St George-Hyslop; L. Lannfelt


Book ID
117413804
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
141 KB
Volume
17
Category
Article
ISSN
0197-4580

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Familial Alzheimer's disease (AD) is an autosomal dominant disorder characterized by memory impairment and multiple cognitive deficits which occurs in mid to late life. Early onset AD has been associated with mutations in three genes, of which presenilin 1 (PS1) mutations are the most frequent. We s