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5-Substituted 3,4-dihydro-3-amino-2H-1-benzopyran derivatives: synthesis and interaction with serotoninergic receptors

✍ Scribed by R. Rezaie; B. Joseph; J. B. Bremner; P. Delagrange; C. Kopp; R. Misslin; B. Pfeiffer; P. Renard; G. Guillaumet


Book ID
111768724
Publisher
Pharmaceutical Press
Year
2001
Tongue
English
Weight
191 KB
Volume
53
Category
Article
ISSN
2042-7158

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Asymmetric synthesis of 4-amino-3,4-dihy
✍ Andreas Burgard; Hans-Jochen Lang; Uwe Gerlach πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 385 KB

Highly enantioselective reduction of 3,4-dihydro-2,2-dimethyl-2H-l-benzopyran-4-ones 3 s-e by BH3 was achieved in the presence of catalytic amounts of Corey's oxazaborolidine 4 to afford the corresponding 3,4-dihydro-2,2dimetbyl-2H-l-~nzopyran-4-ols 2a-e in quantitative yields. These benzopyran-4-ol