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5'-Nor anhydrovinblastine : Prototype of a new class of vinblastine derivatives

✍ Scribed by P. Mangeney; R.Z. Andriamialisoa; J.-Y. Lallemand; N. Langlois; Y. Langlois; P. Potier


Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
439 KB
Volume
35
Category
Article
ISSN
0040-4020

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The synthesis of 3-[ [[2-amino(4-azido-2-nitphenyl)ethyl]amino]carbonyl]-04-deacetyl-3-de-(methoxycarbonyl)-vincaleukoblastine (napavin) from vinblastine is described. This new photoreactive cytostatic substance overcomes multidrug resistance of tumor cells.