Synthesis of napavin, a new photoreactiv
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Georgios Nasioulas; Klaus Grammbitter; Koert Gerzon; Herwig Ponstingl
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Article
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1989
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Elsevier Science
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French
β 172 KB
The synthesis of 3-[ [[2-amino(4-azido-2-nitphenyl)ethyl]amino]carbonyl]-04-deacetyl-3-de-(methoxycarbonyl)-vincaleukoblastine (napavin) from vinblastine is described. This new photoreactive cytostatic substance overcomes multidrug resistance of tumor cells.