5 In situ hybridization for the detection of numerical chromosome aberrations
โ Scribed by P.M. Nederlof; S. van der Flier; A.K. Raap; H.J. Tanke; M. van der Ploeg; F. Kornips; J.P.M. Geraedts
- Book ID
- 119104396
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 117 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0165-4608
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At least 50 per cent of all first-trimester spontaneous abortions are cytogenetically abnormal, including trisomy, monosomy X, triploidy, tetraploidy and structural chromosome anomalies. Traditionally, the detection of aneuploidy in fetal tissues is performed by tissue sampling, cell culturing, meta
Double fluorescence in situ hybridization with D N A probes specific for the (peri)centromeric regions of chromosomes 3, 7, 9, I I, 12, 18, and X was performed on fresh isolated nuclei and frozen tissue sections prepared from 2 nodular hyperplasias, 2 adenomas, and 7 papillary carcinomas of the thyr