5-hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone
β Scribed by J.I. Keonig; H.Y. Meltzer; G.A. Gudelsky
- Book ID
- 113221693
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 531 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0091-3057
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Behavioural and pharmacological studies have suggested that anxiety may be an important factor in the initiation of non-opioid analgesia in defeated male mice. In the present study, the effects of three 5-HT1A anxiolytics (buspirone, ipsapirone and gepirone) on basal nociception and defeat analgesia
The effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by the 5-HT~A receptor agonist, 8-hydroxy-2-(di-npropylamino) tetralin (8-OH-DPAT), were examined. Gepirone dose-dependently increased feeding 2 and 4 h after injection, the magnitude of th