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5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait

✍ Scribed by Blairy, S. ;Massat, I. ;Staner, L. ;Le Bon, O. ;Van Gestel, S. ;Van Broeckhoven, C. ;Hilger, C. ;Hentges, F. ;Souery, D. ;Mendlewicz, J.

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 81 KB
Volume: 96
Category: Article
ISSN: 0148-7299
DOI: 10.1002/1096-8628(20000612)96:3<360::aid-ajmg24>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

The pupose of this study was to investigate the relationship between bipolar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5-HTR2a (chromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bipolar patients and 89 normal subjects completed the TPQ questionnaire and were genotyped for 5-HT2a. Bipolar patients scored higher than normal subjects on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect.

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