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5-Fluorouracil-radiation interactions in human colon adenocarcinoma cells

✍ Scribed by Daniel J. Buchholz; Katherine J. Lepek; Tyvin A. Rich; David Murray

Book ID
103725715
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
630 KB
Volume
32
Category
Article
ISSN
0360-3016

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## Abstract 5‐Fluorouracil (5‐FU) is an antineoplasic drug widely used to treat cancer. Its cytotoxic effect has been principally ascribed to the misincorporation of fluoronucleotides into DNA and RNA during their synthesis, and the inhibition of thymidylate synthase (TS) by FdUMP (one of the 5‐FU