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5-Fluorouracil in hepatocellular carcinoma. Report of twenty-one cases

✍ Scribed by John S. Link; Joseph R. Bateman; Warren S. Paroly; Walter J. Durkin; Robert L. Peters

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
327 KB
Volume
39
Category
Article
ISSN
0008-543X

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✦ Synopsis

Twenty-one patients with biopsy-proven hepatocellular carcinoma were treated with oral or intravenous 5-Fluorouracil according to a ramdomized treatment schedule. Twenty-one patients were evaluable for response and toxicity. The two groups were comparable in distribution of pretreatment characteristics. There were no objective responses in either group. This is the largest reported group of patients with hepatocellular carcinoma treated with 5-Fluorouracil. Toxicity occurred in 46% of patients treated, but was tolerable. In contrast to previous reports,l1.l3 we have found that weekly 5-Fluorouracil given orally or intravenously is not of significant value in the treatment of hepatocellular carcinoma.

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