Creatine kinase elevation associated with 5-fluorouracil and levamisole therapy for carcinoma of the colon: A case report
✍ Scribed by Robert J. Cersosimo; Jeong-Min Lee
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 403 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
There have been no reports of creatine phosphokinase (CKJ elevation during levamisole administration. There is only one prior report of CK elevation of noncardiac origin associated with 5-fluorouracil.
METHODS.
A 41-year-old man was diagnosed with Stage B2 colon carcinoma and underwent extensive surgical resection. Adjuvant therapy with 5-fluorouracil and levamisole was initiated after surgery. A complete hematologic and chemistry pro-Ne was obtained during weekly clinic visits.
RESULTS.
The patient's serum CK levels were normal prior to the initiation of chemotherapy but began to rise after 4 weeks of therapy. Isoenzyme analysis revealed that the CK was 100% from skeletal muscle. When the CK level surpassed 1,000 UIL, chemotherapy was discontinued. The CK levels began to decline immediately, falling to normal within 2 months. All attempts to identify a known cause of the enzyme elevation were negative.