5-Chloro-8-quinolyl group as high efficient phosphate protecting group for the synthesis of oligoribonucleotides
โ Scribed by Hiroshi Takaku; Ryuichi Yamaguchi; Tadaaki Nomoto; Tsujiaki Hata
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 259 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
5-Chloro-8-quinolyl group is found to be very suitable for the protecting group on phosphates in the internucleotidic bonds.
๐ SIMILAR VOLUMES
The 1,1,1,3,3,3-Hexafluoro-2-propyl group can be used as a new class of phosphate protecting group for the protecting group of internucleotidic bonds in the oligonucleotide synthesis by the phosphotriester approach . This protecting group is removed easily by treatment with 0 .3 M N 1 ,N 1 ,N 3 ,N''
2,4,5-Tribromo-l-vinylimidazole was prepared from 2,4,5-tribromoimidazole and 1,2-dibromoethane and its Br-atoms were replaced regio~lectively in the order 2 --) 5 ---> 4 via Br --~ MgBr and other exchange reactions. Efficient removal of the vinyl groups from the resulting polyfunctionalized imidazo